|
|
| |
New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
 |
100% Natural and Safe Remedy
People Said About Goutezol Gout Relief
| "week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago |
 |
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers. Even if you are a stranger in the world of food good for gout, once you are through with this article, you will no longer have to consider yourself to be a stranger in it!
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove. We wish to stress on the importance and the necessity of food good for gout through this article. This is because we see the need of propagating its necessity and importance!
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways. A substantial amount of the words here are all inter-connected to and about food good for gout. Understand them to get an overall understanding on food good for gout.
SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes. food good for gout is the substance of this composition. Without food good for gout, there would not have been much to write and think about over here!
|
|
#1 Doctor Recommended Remedy
People Said About Goutezol Gout Remedy
| "I was only 30 when I got a gout attack. Goutezol really helped me to get over the attack in just two days and the ebook helps me with watching what I'm eating. My uncle have had gout problems too, so I recommended your product. Thanks a lot!" Matt, California |
|
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
|
|
|
|
| |
| |
|
|
|
|
|
|
| |
| |
Learn More about Natural Gout Remedy
According to the National Arthritis Foundation, one in five American adult's suffers from arthritis. This means almost 45 million American's feel this excruciatingly pain consistently. In addition, as the population ages, the number of people experiencing arthritis pain is expected to increase dramatically. So with all of the prescription drugs available to help fight joint pain, why is a tiny... 
The problem with gout is that in most of the cases it is a misunderstood disease. Gout is caused by the increase of the uric acid crystals in the joints or in the surrounding tissues. Gout develops various symptoms that usually involve pain. These symptoms may include warmth, swelling and extreme sensitivity of the affected joints. In more than 50 % of the cases big toe joint affection is seen in...
Our society is such that on a daily basis we unknowingly introduce our bodies to countless foreign substances. We are so conditioned to our way of life that we are not conscious to the fact that almost everything we eat, drink, breathe and put in or on our bodies is full of any number of food dyes, additives and preservatives. We routinely ingest toxic and often deadly chemicals such as chlorine...
The word gout may make you think of kings and medieval history. But gout isn't a disease of the past. It's very much with us today. That's because gout is an inflammatory joint disease and a form of arthritis, not some mysterious illness of the rich and powerful.
There are many natural remedies for Gout, but the most effective may be prevention. Prevention of Gout is only a few lifestyle...
Rheumatoid arthritis is a systemic disease that begins with severe pain in the small joints of hands and feet, spreading to the wrists, knees, shoulders, ankles, and elbows. Overlying skin appears red and shiny. This condition affects mostly women, often beginning between the ages of 20 and 40, although it can occur at any time. Symptoms include joint pain, swelling, and stiffness, accompanied by...
cure for gout pain | gouty tophi tophus | acid elevated uric | colchicine therapy | colchicine and fmf | food good for gout |
|
|
|
| |
| |
|
|
| |
|
|
|
|
