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New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes. It was really tough getting information about anything previously. Now with the advent of the Internet, anyone can access any information at any time of the day.
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This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least. There are no boundaries on countries for one to access information about good food for gout through the Internet. All one has to do is to surf, and then the required matter is availed!
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe. You actually learn more about good food for gout only with more reading on matters pertaining to it. So the more articles you read like this, the more you learn about good food for gout.
HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009. You must have searched high and low for some matter for good food for gout, isn't it? That is the main reason we compiled this article for you to get that required matter!
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In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers. It is not always that we just turn on the computer, and there is a page about good food for gout. We have written this article to let others know more about good food for gout through our resources.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels. Now while reading about good food for gout, don't you feel that you never knew so much existed about good food for gout? So much matter you never knew existed.
It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways. Writing about good food for gout is an interesting writing assignment. There is no end to it, as there is so much to write about it!
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
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Learn More about Natural Gout Remedy
I get numerous e-mails from people asking if there is a cure for gout. As a natural health expert, I have to tell them "No" and "Yes". From a medical standpoint there is no declared cure for gout. However, as researched-based remedies have shown, there are gout natural remedies that can cure gout symptoms. In other words, you never have... 
Gout is a health problem resulting because of the deposit of uric acid crystals in the joints and surrounding tissues. It is characterized by an excess of uric acid in the body that deposits in different parts of the body leading to recurring attacks of joint inflammation. We know two types of gout: acute and chronic. The most severe phase of gout is chronic gout that beside joint inflammation...
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Red clover has been used traditionally as gout herbal medicine for centuries due to its ability to remove toxins from the body. However, using red clover isn't without its side effects. Scientists are now seeing that red clover thins the blood, so it should not be taken without the guidance of a doctor or other health professional. If you are already on anticoagulant medicine, red clover should...
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